This unpretentious Williamsburg restaurant is outfitted in deep wood tables and chairs imported from Mexico, to transport taco lovers south of the border. The mechanical bull in this former warehouse space may be the pre-dinner lure, but stay for the tacos and pair them with frozen margaritas or sangritas, with a rainbow’s worth of flavors to add. Order up a Don Pepito, made with Tequila Cazadores, ginger liqueur, triple sec, and lime juice.

Four unique agave-tasting flights and 10 types of margaritas ensure that you won’t leave El Vez without expanding your tequila knowledge. And a few tacos on the side help sop up all the spirits so you can keep drinking. Roasted brussels sprouts with cashew crema, pork belly carnitas, and grilled or fried fish are just a few of the fillings the tortillas can embrace.

A good night in Tribeca (or Hell’s Kitchen, there are two locations) ends with a margarita at Añejo’s bar or sidewalk cafe, made with just the right proportions of citrus, Cointreau, tequila, and a dash of agave for subtle sweetness. Those looking for a riff on the traditional lime-based drink can also indulge in the spicier version shaken with Tapatio, reposado, grenadine, fresh lime, and spiced salt on the rim — not to outshine an order of short rib tacos with chipotle crema.

Calling this trendy taqueria Manhattan’s favorite taco spot wouldn’t be an exaggeration — crowds are so encapsulated with La Esquina (which means, “The Corner”) that the small restaurant has opened two uptown offshoots. At the flagship, you can choose from elevated tacos like rib eye with queso, rotisserie chicken with salsa verde, and garlic butter-coated shrimp served with bacon, lettuce, and pico de gallo, to eat on the bustling sidewalk cafe or inside the humble diner.

Beloved (or otherwise) in the neighborhood for the iconic oversized margarita statue tipping out of the exposed brick walls, a Taco Tuesday at Caliente is a bucket list item for any New Yorker. Nights often start here at the interactive salsero station where guests customize guacamole smashed in a molcajete and progress to tacos filled with the traditional fillings and some more new-school options, like crispy panko-crusted cauliflower.

It’s easy to spend an entire night at Dos Caminos, munching on guacamole from a molcajete, topped with chapulines (Oaxacan grasshoppers) if you’re craving some protein. Tacos are served on handmade corn tortillas or over grains and greens for those cutting carbs, and a slew of margaritas (or beers topped with frozen marg) flow all night. The frozen prickly pear cactus margarita offers a hint of sweetness to pair with the attractively hot pink color, while the grilled grapefruit version offers just the right amount of citrus-induced pucker.

Mexican comfort food is seared on a wood-fired mesquite grill at this cozy restaurant where sizzling fajita platters offer a DIY taco-ish option. Given the neighborhood, Murray Hill, know that Sinigual isn’t shy about encouraging margarita imbibers, as evidenced by the 21-ounce El Dueño, served in a chalice otherwise reserved for margarita royalty. For a smaller-sized marg that’s still big in flavor, order the grilled pineapple margarita, made with Tequila Cazadores Reposado, fresh grilled pineapple, and jalapeño, served with a chile piquin rim.

This tri-level restaurant and club is a go-to in Times Square for Mexican food and drinks, as well as music and dancing. Stay seated for grilled chicken, steak, fish, shrimp, or veggie tacos, all drizzled with chile con queso, then choose from one of nearly 30 flavors of margarita and head upstairs to work up an appetite for round two.